Erectile dysfunction is a repeated inability to get or maintain a firm erection to complete sexual intercourse in older men. Erectile dysfunction usually has a physiological cause, such as illness or side effects of other medications or disorders that impair nerves or interfere with blood flow to the penis. The usefulness of stem cells in medicine and platelet-rich plasma continues to rise, and are currently being used for this treatment in many research centers worldwide. This new discovery is changing the treatment of erectile dysfunction. Freshly isolated stem cells are injected in several areas of the cavernous body of penis in order to induce smooth muscle regeneration, neuronal regeneration, and endothelial function restoration.